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Blistering Disorders

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Blistering disorders (pemphigus vulgaris, pemphigus foliaceous, bullous pemphigoid, epidermolysis bullosa) are a heterogenous group of disorders that affect the skin and mucous membrane. These diseases all present with either blisters or evidence of broken blisters.

Causes of Blisters

Autoimmune diseases can produce blisters when antibodies attack the skin cells. This creates an opening between the two layers of skin in which fluid accumulates. Epidermolysis bullosa is an inherited condition that is caused by a defect in a gene that holds the skin together. When that gene doesn’t work properly, the skin breaks easily sometimes forming blisters and other times resulting in open wounds. 

Symptoms of Blisters

  • Recurrent blisters on the skin
  • Skin that breaks easily and forms open wounds
  • Open wounds in the mouth

Treatments for Blisters

Treatments for blistering disorders are entirely dependent on the disorder. The autoimmune blistering disorders may be hard to diagnosis. There are multiple procedures that may be done in the office to help diagnosis these disorders including biopsies. Treatment may vary from topical creams to pills. Epidermolysis bullosa is an inherited disorder that is caused by a lack of gene or protein that the skin needs to maintain its structure. Currently scientists are working to try and help patients replace this gene or protein so treatment mainly consists of helping patients with wounds when they arise, preventing wounds and treating skin infections in the wounds.

If you feel your child is experiencing any of these symptoms, please contact Florida Center for Pediatric Dermatology at 407.303.1687 or through our online contact form.